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When to seek specialist input: Inadequate response to first-line pharmacotherapy after 6 months Complex medical history (cardiovascular disease, psychiatric conditions) BMI 40 kg/m or 35 kg/m with significant comorbidities Considering any off-label or combination treatment Patient safety advice: Always discuss treatment options with your GP or obesity specialist before making changes
If yes, dose escalation under medical supervision may be the simplest lever
The regulatory agency cited sufficient lapses in quality control
However, more serious risks, such as pancreatitis and potential thyroid tumors, have been associated with semaglutide use
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