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Moiz noted that oral semaglutide and orforglipron (Eli Lilly), which were also as effective as currently available agents

Despite the negative effects of exenatide on bone fracture risk found in the above meta-analysis, a study of 69 metformin-treated subjects with T2D randomized to exenatide twice-daily (n = 36) or insulin glargine once-daily (n = 33) showed that bone mineral density was similar in both groups after the 44-week therapy (between-group difference p = 0.782)