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Novartis' PI3K inhibitor Vijoice (alpelisib) got a green light for a new indication, treating severe PIK3CA-related overgrowth spectrum (PROS) disorders, to go alongside its current use in breast cancer, where it is facing strong competition from Roche's rival PI3K-targeting drug Itovebi (inavolisib)

Key variants include GLP1R rs6923761 (receptor sensitivity), GIPR rs1800437 (glucose-dependent insulin secretion), and FTO rs9939609 (baseline appetite drive)

It can be uncomfortable and may require changes in diet and hydration habits

Food and Drug Administration announced it has received reports of adverse events after people took injections of semaglutide that came from compounding pharmacies