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demonstrated L-ASNaseinduced autophagy and apoptosis in U87MG and U251MG glioblastoma cells ( in vitro ) and reported enhanced tumor growth inhibition when autophagy was pharmacologically blocked in U87 xenografts ( in vivo )

Druckers data were published a few months later, in May

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(IX) Slug can mediate activation of c-Met in a ligand-independent manner because of increased levels of fibronectin and induced integrin V function ( The HGF/c-Met axis has an important role in cellular behaviors, such as cell proliferation, migration, survival, morphogenesis and the epithelialmesenchymal transition (EMT) (Taher et al., 2002