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Reduced melanin production translates to fewer dark spots, less hyperpigmentation, and a more even skin tone over time

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Ligand binding assays Direct ligand binding experiments were performed using the HTRF signal between GHSR labeled at its N-terminus with Lumi-4 Tb and a ghrelin peptide labeled with dy647 on an additional cysteine positioned at its C-terminus 33

This decline is called somatopause, and it contributes to many age-related changes: loss of muscle mass, increased body fat, decreased bone density, impaired cognitive function, reduced skin elasticity, and weakened immune response