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These effects are generally mild to moderate in severity and tend to diminish over time as patients develop tolerance ^1

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While the histological data presented here do not definitively prove the absence of synapses between L-cells and vagal fibers, they contribute to the growing body of literature indicating that enteroendocrine cells primarily communicate through paracrine mechanisms

[DOI] [PMC free article] [PubMed] [Google Scholar] 23.Vukojevic J., Siroglavic M., Kasnik K., Kralj T., Stancic D., Kokot A., Kolaric D., Drmic D., Sever A.Z., Barisic I., et al