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Materials and methods: 267 subjects with high-risk prediabetes (age 5910 years, BMI 32,5 6,2 kg/m

If you miss more than 4 weeks, restart at a lower dose than where you left off, typically dropping back one or two dose tiers to allow readaptation

Dose assessment: Conservative starting doses may not produce noticeable effects in some individuals

The impairment of the negative feedback was hypothesized to be due to the diminished sensitivity of the glucocorticoid receptors (the glucocorticoid resistance theory) secondary to reduced receptor function and expression, shown in large number of experimental, biological and molecular studies (258)