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A deficiency in methionine synthase function arising from mutations in its gene, known as MTR, gives rise to what is termed a CblG defect

Materials and methods Cell lines MCF-7 (HTB-22), T47-D (HTB-133), MDA-MB175VII (HTB-25), HCC1428 (CRL-2327), and BT-483 (HTB-121) cell lines were obtained from American Type Culture Collection (ATCC), MFM-223 (ACC 422), Cal-519 (ACC 302), and Cal-120 (ACC 459) cell lines were from Leibniz Institute DSMZ, and Sum149PT (HUMANSUM-0003004), Sum159PT (HUMANSUM-0003006) cell lines were from Bioivit

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The 2 class contains the 2A , 2B , and 2C receptors