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Future progress requires developing advanced delivery systems, applying multi-omics approaches to elucidate mechanisms, investigating synergistic drug combinations, and exploring gut microbiota interactions

Interest broadened sharply after Yang and colleagues (Cell, 2014) used targeted metabolomic profiling across twelve ferroptosis-inducing small molecules and found that glutathione depletion converges on inactivation of the selenoenzyme glutathione peroxidase 4, placing glutathione availability directly upstream of iron-dependent lipid peroxidation

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