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Lastly, women with Se deficiency, when compared to women with normal Se concentrations, showed an approximately eight-fold higher risk of preterm delivery) and of delivering at term a low birth weight infant [12]

This overexposure pattern depletes intracellular antioxidants, disrupts redox balance and leads to adverse effects, including cell apoptosis, proliferation inhibition, and functional impairment

This area of research deserves a separate attention and is discussed in the next section of this review

Early Cellular-Level Changes (Preclinical Findings) The earliest documented changes occur at the molecular level, within hours of receptor binding, and are not observable without laboratory measurement