In a systematic review and meta-analysis of four randomized controlled trials including over 3,700 subjects, combination therapy with an SGLT2 inhibitor and metformin beginning at diabetes diagnosis resulted in greater weight loss and reduction of HbA1C levels compared with either drug alone
The FDA recently approved a new indication for use for Wegovy (semaglutide) injection to reduce the risk of heart attack, cardiovascular death and stroke
Key immunomodulatory actions include enhanced phagocytic activity of peripheral leukocytes, upregulated secretion of immunoglobulins (IgA, IgG, and IgM), and increased production of cytokines such as interleukins, TNF-, and interferon- (IFN-) (488)
Furthermore, the learned intermediary doctrine may complicate efforts of plaintiffs with these types of injuries to recover, because gastrointestinal issues are a well-known side effect of GLP-1 receptor agonists, making it more likely that a plaintiffs prescribing physician had adequate warning of the risks
