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Its mode of action includes directly acting on the transcriptional regulatory sites of downstream response target genes after activation, or transmitting signals after interacting with upstream and downstream factors, and integrating multiple signaling pathways to respond to abiotic stress (Roy, 2016

Hypoxia-induced acidosis and lactate accumulation further dampen cytotoxic T-cell and NK-cell function, while aberrant angiogenesis perpetuates perfusion defects and sustained oxygen gradients, reinforcing a vicious cycle of adaptation and selection

Covariates Covariates included age, sex, educational level (as total year of formal education), obtained from structured interviews conducted at the beginning of the study, as well as metabolomic assessment shipment (first vs second)

BPC-157 does not fit into either category based on available data