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Experimental studies have demonstrated that a copper-deficient diet exacerbates myocardial dysfunction in HF models [205]

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In SLE, oxidative stress inhibits ERK signaling in CD4+ T cells, decreases DNMT1 expression and induces promoter demethylation with aberrant overexpression of normally silenced genes, thus mechanistically associating inflammatory stress to erosion of the T-cell methylome (109-111)

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Interestingly, the levels of superoxide dismutase have been found to be high in chronic schizophrenic patients (Reddy et al

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