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Consistent with the loss-of-function effects of genetic variations in human CAMKK2 , mice lacking Camkk2 display behavioural traits similar to those frequently observed in bipolar disorder [33]

Additionally, transferrin-conjugated nanoparticles delivering doxorubicin showed cytotoxicity in myeloid leukemia cells in vitro and in vivo (190, 191)

Results from another uncontrolled intervention in 21 HIV-positive patients suggested that long-term (two to four years) oral ALCAR supplementation (1.5 g/day) may be a beneficial adjunct to antiretroviral therapy to improve neuropathic symptoms in some HIV-infected individuals (80, 81)