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Diabetic cognitive dysfunction is one of the complications of diabetes and is affected by multiple factors, such as nervous system disorders, neuroinflammation and oxidative stress ( Glucagon-like peptide-1 (GLP-1) is an incretin hormone, glucagon-like peptide-1 receptor (GLP-1R) agonists play an important role in the treatment of diabetes ( Daphnetin is an active ingredient with broad application prospects and has been used in the treatment of various diseases ( in vitro , daphnetin protected against methylglyoxal-induced PC12 cell damage, which proved that daphnetin exerted a neuroprotective effect

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Furthermore, a dependence on the use of metformin as a prophylactic to delay aging could serve to decrease the incentive to pursue the proven benefits of lifestyle changes such as improved diet and exercise

2005, doi: 10.1016/j.jacc.2005.04.064