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Further label updates may occur as Novo Nordisk, Ozempics manufacturer, releases more study data

Use: In combination with a reduced calorie diet and increased physical activity, for the treatment of noncirrhotic MASH with moderate to advanced liver fibrosis (consistent with stages F2 to F3 fibrosis) Usual Pediatric Dose for Weight Loss 12 YEARS AND OLDER: Wegovy Injection: Initial dose (weeks 1 through 4): 0.25 mg subcutaneously once a week Dose escalation: Weeks 5 through 8: 0.5 mg subcutaneously once a week Weeks 9 through 12: 1 mg subcutaneously once a week Weeks 13 through 16: 1.7 mg subcutaneously once a week Alternatively: 1.7 mg subcutaneously once a week Comments: The recommended maintenance dose is 2.4 mg

Key considerations for protein targets: Use ideal body weight (IBW) or adjusted body weight for calculations, not current weight in patients with obesity Distribute protein across meals rather than concentrating in one sitting Monitor for signs of inadequate intake: fatigue, weakness, hair loss, or poor wound healing Reassess needs every 36 months as weight changes Consult with a registered dietitian for personalized recommendations GLP-1 receptor agonists and dual GIP/GLP-1 receptor agonists exert their appetite-suppressing effects through multiple mechanisms