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2018), so it was useful to consider VPA treatment in this study as a reference to compare the relative proposed antiepileptic effect of EMPA to it

However, since case reports typically highlight severe or unusual outcomes, their inclusion might have exaggerated the perceived risk and may not reflect the true incidence in larger populations

Nevertheless, results from large cardiovascular outcome trials relating to the use of GLP-1 agonists indicate that the proportion of participants discontinuing GLP-1 receptor agonists due to adverse gastrointestinal events ranges between 4.5 to 13% (100)

Known side effects at standard doses include delayed gastric emptying, gallbladder-related issues, and more rarely, a risk for acute pancreatitis, though as mentioned above these appear to be less common at lower doses