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In multivariate analyses, factors predicting larger responses with tirzepatide include female sex (2.4 higher odds of achieving a 20% weight reduction), lower baseline hemoglobin A1c (1.62 higher odds), no diagnosed hypertension (1.35 higher odds), and lower ALT (1.17 higher odds) [21]

Coleman MD, Rhodes LE, Scott AK, et al

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The drug's lack of efficacy on weight loss may raise questions of what the fuss is all about, but there is just one obvious problem: the clinical trials tested a fat-burning pill and allegedly at much lower doses than that given to the footballers