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However, the requirement for HSL phosphorylation has recently been challenged as studies by the Granneman group elegantly show that direct activation of PNPLA2 in the absence of PKA stimulation is sensitive to HSL inhibition, suggesting that PNPLA2-mediated generation of DAG is sufficient to promote HSL activity (49)

This reaction is wasteful in 2 really important ways

Thanks to the Vegan Society for allowing us to link to their website: Devalia V et al (2014) Guidelines for the diagnosis and treatment of cobalamin and folate disorders [Accessed 29.11.19] Linnebank et al (2011) Antiepileptic drugs interact with folate and vitamin B12 serum levels [Accessed 22.10.19] Sukumar and Saravanan (2019) Investigating Vitamin B12 deficiency [Accessed 29.11.19]

People with a specific variant of the MTHFR (methylenetetrahydrofolate reductase) gene have an impaired ability to break down and use folate