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Int J Pharm 669:125055

Mecobalamin plays a key role in nerve cell repair, while Pyridoxine and Nicotinamide support proper nerve metabolism and signal transmission, helping reduce symptoms like numbness, tingling, and burning sensations

Runx2/Osterix pathway: Upregulation of Runx2 (osteogenic differentiation core transcription factor) and Osterix expression induces directed differentiation of bone marrow mesenchymal stem cells into osteoblasts and increases new bone formation

[13] [14] Deficiency impairs these pathways, leading to fatigue and reduced stamina One-carbon metabolism : B12 supports methylation reactions that contribute to various biochemical processes throughout the body Myelin formation : B12 supports the maintenance of myelin sheaths surrounding nerve fibres, ensuring efficient nerve signal transmission Red blood cell production : Adequate B12 is necessary for erythropoiesis