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In addition, although overweight and obesity is markedly more common, some individuals with advanced HF like HFrEF are also cachexic (Rossignol et al., 2015) and may therefore not benefit from the weight-reducing effect of GLP-1 RAs

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GLP-1 RAs act by stimulating insulin secretion in a glucose-dependent manner, inhibiting glucagon release, and slowing gastric emptying, which together improve overall metabolic control and reduce appetite (Nathan et al