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Its not that it cant work, its just that its often used incorrectly

Kidney Int 71:116125 List EO, Sackmann-Sala L, Berryman DE, Funk K, Kelder B, Gosney ES, Okada S, Ding J, Cruz-Topete D, Kopchick JJ (2011) Endocrine parameters and phenotypes of the growth hormone receptor gene disrupted (GHR-/-) mouse

In other words, it is possible for patients to maintain weight while stopping the medication but some patients may also gain weight at a faster rate or a greater degree than what is seen in the scientific studies, says Lofton

This GTPase and translation termination factor is one of several usual suspect CRBN (cereblon) neosubstrates