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I'd add an evolutionary lens to this discussion - if we consider that humans are hypercarnivores based on our digestive anatomy and evolutionary history, "insulin resistance" becomes less about pathology and more about normal physiology responding to an unnatural food environment

Just recently, Bar and colleagues found, the polycomp repressive complex 1 (PRC1), a chromatin remodeling complex, to prevent ectopic Shh expression in non-taste lingual epithelium in the developing tongue [172]

Semaglutide injections are FDA-approved treatments that were initially used for managing diabetes but have shown significant efficacy in promoting weight loss

Akbay, E., Erdem, B., nl, A., Durukan, A