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While early immune responses may aid in the clearance of A and tau aggregates, prolonged activation of microglia and astrocytes leads to chronic inflammation and the release of pro-inflammatory cytokines such as IL-1 and TNF-, promoting neuronal damage in vulnerable brain regions like the neocortex and hippocampus [34,35,36]

And I think that there are two areas that I learned about recently through the podcast that have completely reframed the way I think about traditional and modern medicine