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Description

It includes a boxed warning for thyroid C-cell tumors, based on rodent data, and it is contraindicated in people with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 (MEN2)

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Nat Med (2009) 15(6):6235

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Mammalian autophagy: core molecular machinery and signaling regulation

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The modified structure of MT-I leads to an enhanced half-life and increased affinity to the melanocortin receptor 1 (MC1R), which predominantly regulates melanogenesis [3]

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