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Add water slowly: - Draw 2 mL bacteriostatic water into syringe - Insert needle into vial, aim water stream at vial wall (not directly at powder) - Inject slowly to minimize foam 3

Exogenous supplementation of lactate resulted in a comprehensive enhancement of the lactate/H3Kla/M2 phenotype conversion axis, indicating that lactylation acts as a protective mechanism, facilitating timely self-adjustment in response to inflammatory environments [47]

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All care begins with a comprehensive medical evaluation to determine eligibility, safety, and the most appropriate treatment options