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A longitudinal cohort study published in the Journal of Neuroinflammation found that declining circulating glutathione levels were associated with reduced executive function over four years in a healthy population of nearly 500 adults, independent of inflammatory markers

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In a mouse model of WHS with deletions of the Nsd2 gene, the animals exhibited growth retardation, midline, craniofacial, and ocular abnormalities, but showed no signs of learning deficits (Naf et al., 2001)