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Testing positive can result in suspensions or permanent bans from sanctioned competition (WADA Prohibited List, 2024)

[DOI] [PMC free article] [PubMed] [Google Scholar] Yehuda R, Southwick S, Giller EL, Ma X, Mason JW (1992) Urinary catecholamine excretion and severity of PTSD symptoms in Vietnam combat veterans

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And its not because of any magic its because these are natural substances that our bodies make and are familiar with, so thats what gives them this incredible safety profile. The FDA, however, has publicly stated that there is not enough evidence from human clinical trials on the safety or efficacy of these drugs