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Common signs of B12 deficiency include: Persistent fatigue that doesnt improve with rest Difficulty concentrating or brain fog Mood changes, including low mood or irritability Tingling or numbness in the hands and feet Weakness or shortness of breath with normal activity Pale skin or a smooth, swollen tongue B12 deficiency can develop silently for months before symptoms become noticeable, which is why its frequently missed

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Beyond simple actin sequestration, Bock-Marquette and colleagues reported in Nature (2004) that T4 activates integrin-linked kinase and Akt, promoting cardiomyocyte and epicardial cell migration and survival in mouse cardiac injury models, which established a signalling role separate from cytoskeletal buffering