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The Importance of FIH Trials in Clinical Development First-in-Human trials provide the first opportunity to translate preclinical evidence into early clinical knowledge

Furthermore, it has been observed that in animal models of T2D, islet macrophages undergo local expansion and specific transcriptional changes, with two distinct subsets identified: intra-islet (CD11c + ) and peri-islet (CD11c - ) macrophages

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