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This review aims to summarize current pathogenesis, diagnostics and treatment algorithms for DPN with the focus on modern methods such as the use of artificial intelligence, corneal confocal microscopy and recent treatment advances

The impairment of the negative feedback was hypothesized to be due to the diminished sensitivity of the glucocorticoid receptors (the glucocorticoid resistance theory) secondary to reduced receptor function and expression, shown in large number of experimental, biological and molecular studies (258)

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Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation