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High-dose vitamin B12 injections can cause immunologically induced skin reactions, which is why an amount adjusted to the individual blood level is recommended for supplementation among vegans to avoid possible vitamin B12 side effects
By day 4 after a missed dose, drug levels have dropped enough that adding a late dose on top of what remains could create unpredictable effects
However, for musculoskeletal and systemic applications, subcutaneous injection delivers the peptide directly into systemic circulation at predictable concentrations
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