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That trial also reported a primary composite cardiovascular endpoint of 6.5% with semaglutide versus 8% with placebo, a hazard ratio of 0.80 (95% CI 0.72 to 0.90)

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The calculators also don't account for peptide degradation

16 HOW SUPPLIED/STORAGE AND HANDLING How Supplied Single-patient-use pens (with multiple weekly doses): Injection: clear, colorless solution of 0.68 mg/mL, 1.34 mg/mL or 2.68 mg/mL of semaglutide available in the following packaging configurations: Each OZEMPIC multi-dose pen is for use by a single patient