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Shah RM, et al

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GLP-1 medications may carry serious risks, including thyroid C-cell tumor warnings, pancreatitis, gallbladder problems, kidney complications, gastrointestinal side effects, an increased risk of low blood sugar when used alongside certain diabetes medications, allergic reactions, pregnancy-related warnings, and other medication-specific risks

Thus, the improvement in glycemic levels after the pharmacological treatments may justify the reduction in the activity of this enzyme