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Separately, GLP-1 drugs appear to reduce alcohol cravings: a May 2026 Lancet trial found semaglutide cut heavy drinking days by 41% versus 26% on placebo in adults with alcohol use disorder and obesity

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Absolute contraindications include hypersensitivity to any component, severe hepatic failure, and sulfur-amino-acid disorders such as homocystinuria

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Rheumatoid arthritis: IFN drives synovial tissue remodelling

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