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This association between Hp infection and GC has been confirmed in certain animals species such as gerbils and mice, indicating that Hp infection may lead to GC accompanied by and over-expression of gastrin and other growth factors, enhanced COX-2 - PG system, an increase in generation of pro-inflammatory cytokines with the polymorphism in their genes, apoptosis and angiogenesis with invasion of the malignant cells into the surrounding tissues