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Timing and Circadian Effects The pituitary also has intrinsic rhythmicity and responsiveness that varies throughout the day and in different metabolic states - somatotrophs are more responsive to GHRH stimulation during certain circadian phases (particularly during sleep), after exercise, during fasting, and in the presence of ghrelin (the "hunger hormone" that synergizes with GHRH to amplify GH release)

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How Clinicians Decide Whether EstroGel (or Other Forms of Estradiol Gel) is Right for You Your clinician will ask you a handful of questions to help you decide whether EstroGel is right for you

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