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Conversely, inhibition of diglyceride acyltransferase 2 with antisense oligonucleotides in db/db mice fed a methionine and choline-deficient diet-reduced hepatic steatosis, but augmented hepatic inflammation, fibrosis, and apoptosis [71]

The GPXs mediate the same reaction as catalase, namely, the recycling of hydrogen peroxide into water

It is thought that the benefits accrue from reduced inflammation, reduced deposition of beta amyloid and enhanced brain metabolism