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Lysyl oxidase (LOX)mediated collagen cross-linking further increases ECM rigidity, which in turn activates integrinFAKYAP/TAZ and Wnt/-catenin signaling pathways, and promotes epithelialmesenchymal transition (EMT) and fibrogenesis (126)

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A primary deficiency means that there is a genetic disorder that would cause the body to not produce sufficient levels of carnitine

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