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Clinical trials (e.g., SCALE) show that highdose liraglutide can produce significant weight loss and improvements in prediabetes, lipids, and blood pressure when combined with a reducedcalorie diet and increased activity

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doi: 10.1016/j.pan.2019.03.006 94 KhanSAl HerakiSKupecJT

Another deleterious pathology associated with mTOR activation is insulin resistance which can lead to suppressed glucose metabolism and insufficient ATP production (Di Domenico et al