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Excess iron inhibited the SIRT1-autophag y axis in foam cells and decreased GPX4 expression, collectively inducing foam cell ferroptosis

[DOI] [PubMed] [Google Scholar] Booker FL, Burkey KO, Jones AM

Synthesis and study of 2-(pyrrolesulfonylmethyl)- N -arylimines: a new class of inhibitors for human glutathione transferase A1-1

FIGURE 2 5.2 Clinical application of intranasally delivered drugs Although IN delivery of iron chelators remains in the early preclinical stages and has not yet entered clinical trials, the broader field of IN route has gained increasing attention over the past decade, as evidenced by a notable rise in related clinical studies