Under the same exposure protocol, we observed the activation of the NGF/TrkA pathways in the cerebellum ( FIGURE 2 FIGURE 3 These results indicate that systemic treatment with BSO induces the synthesis of NGF by peripheral tissues, as well as the NGF and TrkA protein levels and TrkA phosphorylation in the striatum, possibly as a response to systemic oxidative stress induced by GSH depletion after BSO treatment (Table 2), suggesting that NGF is a redox sensor in both the peripheral tissues and striatum
Figure 3c,d depict the changes in serum AST and ALT levels over time after ethanol administration
HGF/c-Met signaling pathway with its downstream effector components (MAPK, STAT, PI3K-AKT cascades and NF-B) increase cell survival, motility and proliferation [51]
Like glucuronidation, around 30-35% of PCM undergoes sulfation to increase the solubility of paracetamol, aiding in its elimination from the body (Ramachandran & Jaeschke, 2019)