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For most people with straightforward B12 deficiency due to dietary insufficiency , oral cyanocobalamin at doses of 50-150 micrograms daily between meals is the standard UK recommendation

[21] Within cells, cyanocobalamin is converted to methylcobalamin and 5- deoxyadenosylcobalamin, coenzymes that participate respectively in homocysteine remethylation to methionine and in the isomerization of methylmalonyl-CoA to succinyl CoA, reactions essential for DNA synthesis, erythropoiesis, and myelin maintenance

A case-control study (Urbanski et al

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