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The Endocrine Society's 2020 position statement on peptide therapeutics emphasizes that "the absence of Phase I dose-escalation data for novel peptides like BPC-157 means that any dose recommendation is extrapolated, not validated, and clinicians should err on the side of the lowest effective dose" 19

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Its selectivity for NNMT (IC50 values in the low micromolar range) means it increases NAD+ by preserving nicotinamide availability rather than directly supplementing NAD+ precursors