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In a study by Elovaris et al., intraduodenal administration of l-valine at moderate and at supraphysiological doses to healthy young men had no effect on energy intake or blood glucose regulation, suggesting that l-valine does not have important glucoregulatory or appetite-suppressant effects in humans [39]

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Drucker agreed that these newer drugs do not meaningfully penetrate the brain, but Secher, Rinaman, and others have shown they do meaningfully signal to many regions deep within the brain