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This work is supported by an intramural grant from the National Centre for Cell Science (NCCS) and the authors would like to acknowledge the support of G.C

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The restraints were derived from (i) NOE restraints from intermolecular and intramolecular cross-peaks in NOESY spectra (described in NMR spectroscopy section), (ii) TALOS derived p53 TAD2 and FOXO4-DRI backbone dihedral angles, (iii) hydrogen bond restraints (regions p53 residues 4752, FOXO4-DRI residues 918

Overall, our study findings provide a comprehensive understanding of the metabolic impacts of glutathione supplementation and may suggest potential therapeutic benefits in managing oxidative stress-related conditions