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Pharmacology & Therapeutics, 155, 49-59

GLP-1 is an incretin hormone that plays a key role in: Stimulating insulin secretion in response to food Suppressing glucagon release (which raises blood sugar) Slowing gastric emptying, which promotes a feeling of fullness Reducing appetite and food intake This is the same pathway targeted by GLP-1 receptor agonist medications though berberine acts upstream by encouraging the bodys own GLP-1 production, rather than mimicking the hormone directly

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