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Results: MTX altered the concentration of 31 out of 70 metabolites analyzed, suggesting inhibition of the glycine cleavage system, the pentose phosphate pathway, purine and pyrimidine synthesis, phospholipid metabolism, and bile acid uptake

Strong appetite suppression - usually a feature, sometimes uncomfortable

Both oxidative and nitrosative stress are associated with muscle wasting in tumour-bearing rats

Patients should begin shifting focus during their final months of treatment toward building three non-negotiable habits: consistent protein intake (25-35% of daily calories) to preserve muscle and satiety, regular movement that combines strength training and cardiovascular activity at least 150 minutes weekly, and established meal timing patterns that prevent extreme hunger spikes