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Diarrhea affects 15-25% of users
For GLP-1 class compounds such as Tirzepatide and Retatrutide, trial data most commonly documents transient gastrointestinal effects nausea, reduced appetite, and digestive discomfort that typically diminish as dosing stabilizes
analyzed patients initially treated with GLP-1 RAs or SGLT2i, subsequently adding the second agent to evaluate the effects of combination therapy compared to monotherapy and differencing across groups (113, 114)
They may reduce over time with smaller meals, slower eating, and gradual dose escalation as advised by your doctor
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