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(8) This increase was determined by measuring the 12-hour area under the curve (AUC), considered a pharmacokinetic parameter that quantifies the total hormone concentration in the bloodstream over a specified period of time

The ontogeny of growth hormone receptors in the rabbit tibia

Fasting-induced depletion of glutathione in the aging mouse

The foundational characterization appeared in European Journal of Endocrinology in 1998, reporting selective agonism of the growth hormone secretagogue receptor type 1a (GHS-R1a) without significant elevation of ACTH, cortisol, prolactin, FSH, LH, or TSH, even at doses 200-fold above the GH-releasing ED50 in preclinical models